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KMID : 1134820200490060547
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Journal of the Korean Society of Food Science and Nutrition
2020 Volume.49 No. 6 p.547 ~ p.553
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Protective Effect of Propolis Complex against Helicobacter pylori-Induced Stomach Ulcer in C57BL/6 Mouse
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Kim Na-Rae
Lee Seung-Wan
Kwon Hyo-Jung
Kim Mee-Ree
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Abstract
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Digestive ulcers are the most common digestive diseases experienced by 4∼5% of the world’s population at least once in their lifetime. Propolis has been widely used as a health functional food for its efficacy, including antioxidant and antimicrobial effects, against oral bacteria. However, its effect on suppressing stomach damage is not known yet. In this study, after infecting C57BL/6 mice with Helicobacter pylori, a major pathogen for peptic ulcer, the antimicrobial activity of propolis complex mixed with natural materials, olive leaves and/or licorice, was measured through the pathological histologic findings, H. pylori colonization, expression analysis of pre-inflammatory cytokines-related genes, and oxidative stress analysis. As a result, the propolis complex suppressed the ulceration on the damaged gastric mucosa induced by H. pylori and inhibited the bacterial colonization and the inflammation of gastric mucosa in C57BL/6. Especially, compared to propolis only, the propolis complex mixed with olive leaves extract and licorice extract showed significant anti-pylori attachment, antioxidant and anti-inflammatory effects. Therefore, based on these results, we suggest that the proposed propolis composition may have potential to be developed as a material for protecting against stomach ulcers.
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KEYWORD
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propolis complex, Helicobacter pylori infection, stomach ulcer, anti-pylori adhesion, anti-inflammation
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